Endocrine Abstracts

Ghrelin and GHRH are two hormones involved in the growth hormone (GH) secretion through their respective receptors. The growth hormone secretagogue receptor subtype 1a (GHS-R1a) is involved in biological actions exerted by ghrelin triggering intracellular second messengers coupled to Gαq/11 protein. In this work, we analyzed the possible interaction between GHRH and GHS-R1a as well as the subsequent intracellular pathways. The results showed that GHRH induced, ...

Introduction: Recent advances in medicine have allowed a considerably decrease in mortality after traumatic brain injury (TBI) with the consequent increment in the number of subjects with physical, psychological and cognitive sequelas which means an important worsening of quality of life as well as difficulties in social and labour integration. Considering that many of the symptoms classically attributed to the TBI (memory impairment, concentration impairment, fatigue, social ...

Introduction: Ghrelin is a novel peptide involved in the regulation of appetite and energy balance. Dysregulation of ghrelin may play a role in the development of obesity in polycystic ovary syndrome (PCOS). Due to the strong association between BMI and PCOS, we hypothesised that obese women with PCOS have abnormal fasting and post-glucose load ghrelin levels compared with BMI-matched control women.Methods: Datasets included 18 women with PCOS, all with ...

Introduction: Functional GH deficiency has been described in fibromyalgia (FM). The efficacy of GH as add-on treatment has been suggested in small studies, but little is known in larger and homogeneous populations.Design: Patients (120) were enrolled in a multicenter, randomized, placebo-controlled trial for 18 months (NCT00933686). FM impact questionnaire (FIQ) >75 (severe), duration of FM >18 months, and stability of the standard therapy (amitr...